Potassium Channel

KcsA

Potassium Channel

Related Products

Potassium channels are the most widely distributed type of ion channel and are found in virtually all living organisms. They form potassium-selective pores that span cell membranes. Potassium channels are found in most cell types and control a wide variety of cell functions. Potassium channels function to conduct potassium ions down their electrochemical gradient, doing so both rapidly and selectively. Biologically, these channels act to set or reset the resting potential in many cells. In excitable cells, such asneurons, the delayed counterflow of potassium ions shapes the action potential. By contributing to the regulation of the action potential duration in cardiac muscle, malfunction of potassium channels may cause life-threatening arrhythmias. Potassium channels may also be involved in maintaining vascular tone.

Potassium Channel Related Products (739)
Antibodies (5)

By Effects:	Controls (4) Inhibitors (475) Agonists (10) Antagonists (30) Activators (146) Modulators (25) Chemical (1)

Cat. No.	Product Name	Effect	Purity	Chemical Structure

HY-10562A

Ketanserin tartrate	Inhibitor	99.99%
Ketanserin (R41468) tartrate is a selective 5-HT2 receptor antagonist. Ketanserin tartrate also blocks hERG current (I_hERG) in a concentration-dependent manner (IC₅₀=0.11 μM).

HY-17001

Flupirtine Maleate	Activator	99.97%
Flupirtine Maleate is a?brain?penetrant, and orally bioavailable, non-opioid and centrally acting analgesic agent. Flupirtine Maleate is an indirect N-methyl-D-aspartate receptor (NMDAR) antagonist. Neuroprotective properties.

HY-14290

Pinacidil	Activator	99.89%
Pinacidil is a potent activator of potassium channel. Pinacidil is an antihypertensive agent which hyperpolarises vascular smooth muscle by opening K⁺-channels. Pinacidil significantly improves the reperfusion function and cardiac compliance. Pinacidil has direct cardioprotective efficacy.

HY-A0084A

Procainamide	Activator	99.80%
Procainamide (Procaine amide) is a specific and potent inhibitor of DNA methyltransferase 1 (DNMT1), which reactivates the expression of tumor suppressor factors by demethylating tumor suppressor genes. Procainamide induces vacuolization in various cell types and reduces cell proliferation and migration. Procainamide relaxes airway smooth muscle by activating potassium channels. Procainamide can be used in cancer and arrhythmia research.

HY-A0084

Procainamide hydrochloride	Activator	≥98.0%
Procainamide hydrochloride (Procaine amide hydrochloride) is a specific and potent inhibitor of DNA methyltransferase 1 (DNMT1), which reactivates the expression of tumor suppressor factors by demethylating tumor suppressor genes. Procainamide hydrochloride induces vacuolization in various cell types and reduces cell proliferation and migration. Procainamide hydrochloride relaxes airway smooth muscle by activating potassium channels. Procainamide hydrochloride can be used in cancer and arrhythmia research.

HY-110105

NS8593 hydrochloride	Inhibitor	99.81%
NS8593 hydrochloride is a potent and selective small conductance Ca²⁺-activated K⁺ channels (SK channels) inhibitor. NS8593 hydrochloride reversibly inhibits SK3-mediated currents with a K_d value of 77 nM. NS8593 hydrochloride inhibits all the SK1-3 subtypes Ca²⁺-dependently (K_ds of 0.42, 0.60, and 0.73 μM, respectively, at 0.5 μM Ca²⁺), and does not affect the Ca²⁺-activated K⁺ channels of intermediate and large conductance (hIK and hBK channels, respectively).

HY-122015

ASP2905	Inhibitor	99.77%
ASP2905 is a potent and selective potassium channel Kv12.2 inhibitor encoded by the Kcnh3/BEC1 gene. ASP2905 can cross the blood-brain barrier and has antipsychotic activities.

HY-139791

Azetukalner	Activator	99.77%
KCNQ2/3 activator-1 is an activator of Kv7.2/Kv7.3 (KCNQ2/3) potassium channel. KCNQ2/3 activator-1 has the potential in relieving pain (the main problem from medical treatment) (extracted from patent WO2021113757A1, compound A).

HY-15416

NS309	Activator	99.09%
NS309 is a potent and selective activator of the Ca²⁺-activated SK/IK potassium channels, but displays no activity at BK channels.

HY-12343

ML277	Activator	98.46%
ML277 (CID-53347902) is a potent and selective activator of K(v)7.1 (KCNQ1) potassium channel activator (EC₅₀=270 nM), rescues function of pathophysiologically important mutant channel complexes in human induced pluripotent stem cell-derived cardiomyocytes.

HY-110143

CLP257	Activator	99.76%
CLP257 is a selective K⁺-Cl^? cotransporter KCC2 activator with an EC₅₀ of 616 nM. CLP257 is inactive against NKCC1, GABAA receptors, KCC1, KCC3 or KCC4. CLP257 restores impaired Cl^? transport in neurons with diminished KCC2 activity. CLP257 alleviates hypersensitivity in rats with neuropathic pain. CLP257 modulates plasmalemmal KCC2 protein turnover post-translationally.

HY-B0422

Nateglinide	Inhibitor	99.51%
Nateglinide, a D-phenylalanine derivative, is an orally active and short-acting insulinotropic agent and a DPP IV inhibitor. Nateglinide inhibits ATP-sensitive K⁺ channels in pancreatic β-cells. Nateglinide is used for the treatment of type 2 (non-insulin-dependent) diabetes mellitus.

HY-N0221

Daurisoline	Inhibitor	99.90%
Daurisoline is a bis-benzylisoquinoline alkaloid that can be isolated from Menispermum dauricum and Rhizoma Menispermi. Daurisoline exerts a blocking effect on hERG and has antiarrhythmic effects. Daurisoline is a potent autophagy blocker that can be used for the research of cancer.

HY-W020468

Linopirdine	Inhibitor	99.08%
Linopirdine (DuP 996) is an orally active, selective M-type K⁺ current (IM; Kv7; KCNQ Channels) inhibitor with an IC₅₀ of 2.4 μM. Linopirdine is a TRPV1 agonist. Linopirdine, a putative cognition enhancing agent, increases acetylcholine release in rat brain tissue.

HY-12496

NS-1619	Activator	98.06%
NS-1619 is an opener of large conductance Ca²⁺-activated K⁺ (BK) channel. NS-1619 is a highly effective relaxant with an EC₅₀ of about 10?–?30?μM in several smooth muscles of blood vessels and other tissues. NS1619 inhibits proliferation and induces apoptosis in A2780 ovarian cancer cells.

HY-75839

Dronedarone Hydrochloride	Inhibitor	99.99%
Dronedarone Hydrochloride is a non-iodinated amiodarone derivative that inhibits Na⁺, K⁺ and Ca²⁺ currents.

HY-B0254

Glipizide	Inhibitor	99.04%
Glipizide (CP 2872; K 4024)?a potent, orally active and sulfonylurea class anti-diabetic agent and can be used for type 2?diabetes mellitus research but not type 1. Glipizide acts by partially blocking ATP-sensitive potassium?(K_ATP) channels among β cells of pancreatic islets of Langerhans.

HY-B0433A

Quinine hydrochloride dihydrate	Inhibitor	≥98.0%
Quinine hydrochloride dihydrate (Qualaquin) is an orally active and can be used in anti-malarial studies. Quinine hydrochloride dihydrate is a potassium channel inhibitor that inhibits WT mouse Slo3 (K_Ca5.1) channel currents evoked by voltage pulses to +100 mV with an IC₅₀ of 169 μM.

HY-B1302

Quinidine hydrochloride monohydrate	Inhibitor	99.97%
Quinidine hydrochloride monohydrate is an anti-arrythmic agent which is also a potent blocker of K⁺ channel with an IC₅₀ of 19.9 μM.

HY-B0405A

Bupivacaine hydrochloride	Inhibitor	99.89%
Bupivacaine hydrochloride is a NMDA receptor inhibitor.Bupivacaine can block sodium, L-calcium, and potassium channels.Bupivacaine potently blocks SCN5A channels with the IC₅₀ of 69.5 μM. Bupivacaine hydrochloride can be used for the research of chronic pain.

Name
Email *

	Sorry, but the email address you supplied was invalid.

Potassium Channel

Potassium Channel

Potassium Channel Related Products (739)

Antibodies (5)

Potassium Channel Related Products (739):