Potassium Channel

KcsA

Potassium Channel

Related Products

Potassium channels are the most widely distributed type of ion channel and are found in virtually all living organisms. They form potassium-selective pores that span cell membranes. Potassium channels are found in most cell types and control a wide variety of cell functions. Potassium channels function to conduct potassium ions down their electrochemical gradient, doing so both rapidly and selectively. Biologically, these channels act to set or reset the resting potential in many cells. In excitable cells, such asneurons, the delayed counterflow of potassium ions shapes the action potential. By contributing to the regulation of the action potential duration in cardiac muscle, malfunction of potassium channels may cause life-threatening arrhythmias. Potassium channels may also be involved in maintaining vascular tone.

Potassium Channel Related Products (796)
Antibodies (6)
Related Compound Screening Libraries (1)

By Effects:	Controls (6) Inhibitors (504) Agonists (14) Antagonists (33) Activators (158) Modulators (25) Chemical (1)

Cat. No.	Product Name	Effect	Purity	Chemical Structure

HY-P1275

Tertiapin-Q	Inhibitor	99.84%
Tertiapin-Q is a highly selective blocker of GIRK1/4 heterodimer and ROMK1 (Kir_1.1).

HY-110105

NS8593 hydrochloride	Inhibitor	99.81%
NS8593 hydrochloride is a potent and selective small conductance Ca²⁺-activated K⁺ channels (SK channels) inhibitor. NS8593 hydrochloride reversibly inhibits SK3-mediated currents with a K_d value of 77 nM. NS8593 hydrochloride inhibits all the SK1-3 subtypes Ca²⁺-dependently (K_ds of 0.42, 0.60, and 0.73 μM, respectively, at 0.5 μM Ca²⁺), and does not affect the Ca²⁺-activated K⁺ channels of intermediate and large conductance (hIK and hBK channels, respectively).

HY-110110

VU0463271	Antagonist	99.67%
VU0463271 is a selective KCC2 antagonist, with an IC₅₀ of 61 nM.

HY-A0084

Procainamide hydrochloride	Activator	≥98.0%
Procainamide hydrochloride (Procaine amide hydrochloride) is a specific and potent inhibitor of DNA methyltransferase 1 (DNMT1), which reactivates the expression of tumor suppressor factors by demethylating tumor suppressor genes. Procainamide hydrochloride induces vacuolization in various cell types and reduces cell proliferation and migration. Procainamide hydrochloride relaxes airway smooth muscle by activating potassium channels. Procainamide hydrochloride can be used in cancer and arrhythmia research.

HY-110143

CLP257	Activator	99.76%
CLP257 is a selective K⁺-Cl cotransporter KCC2 activator with an EC₅₀ of 616 nM. CLP257 is inactive against NKCC1, GABAA receptors, KCC1, KCC3 or KCC4. CLP257 restores impaired Cl transport in neurons with diminished KCC2 activity. CLP257 alleviates hypersensitivity in rats with neuropathic pain. CLP257 modulates plasmalemmal KCC2 protein turnover post-translationally.

HY-10562A

Ketanserin tartrate	Inhibitor	99.99%
Ketanserin (R41468) tartrate is a selective 5-HT2 receptor antagonist. Ketanserin tartrate also blocks hERG current (I_hERG) in a concentration-dependent manner (IC₅₀=0.11 μM).

HY-139791

Azetukalner	Activator	99.77%
Azetukalner (XEN1101) is a selective and orally active Kv7.2/Kv7.3 potassium channel opener with an EC₅₀ of 27 nM. Azetukalner is approximately 4-fold more selective for Kv7.2/7.3 over Kv7.3/7.5 (EC₅₀ of 94 nM) and Kv7.4 (EC₅₀ of 113 nM) channels. Azetukalner exhibits a selectivity >100-fold for Kv7 channels over other ion channels and receptors. Azetukalner can be used for the study of focal epilepsy.

HY-B0405A

Bupivacaine hydrochloride	Inhibitor	99.89%
Bupivacaine hydrochloride is a NMDA receptor inhibitor.Bupivacaine can block sodium, L-calcium, and potassium channels.Bupivacaine potently blocks SCN5A channels with the IC₅₀ of 69.5 μM. Bupivacaine hydrochloride can be used for the research of chronic pain.

HY-15416

NS309	Activator	99.09%
NS309 is a potent and selective activator of the Ca²⁺-activated SK/IK potassium channels, but displays no activity at BK channels.

HY-17001

Flupirtine Maleate	Activator	99.97%
Flupirtine Maleate is a brain penetrant, and orally bioavailable, non-opioid and centrally acting analgesic agent. Flupirtine Maleate is an indirect N-methyl-D-aspartate receptor (NMDAR) antagonist. Neuroprotective properties.

HY-A0084A

Procainamide	Activator	99.80%
Procainamide (Procaine amide) is a specific and potent inhibitor of DNA methyltransferase 1 (DNMT1), which reactivates the expression of tumor suppressor factors by demethylating tumor suppressor genes. Procainamide induces vacuolization in various cell types and reduces cell proliferation and migration. Procainamide relaxes airway smooth muscle by activating potassium channels. Procainamide can be used in cancer and arrhythmia research.

HY-122015

ASP2905	Inhibitor	99.77%
ASP2905 is a potent and selective potassium channel Kv12.2 inhibitor encoded by the Kcnh3/BEC1 gene. ASP2905 can cross the blood-brain barrier and has antipsychotic activities.

HY-B1302

Quinidine hydrochloride monohydrate	Inhibitor	99.97%
Quinidine hydrochloride monohydrate is an anti-arrythmic agent which is also a potent blocker of K⁺ channel with an IC₅₀ of 19.9 μM.

HY-75839

Dronedarone Hydrochloride	Inhibitor	99.99%
Dronedarone Hydrochloride is a non-iodinated amiodarone derivative that inhibits Na⁺, K⁺ and Ca²⁺ currents.

HY-N0466

Rebaudioside A	Inhibitor	≥98.0%
Rebaudioside A is a steviol glycoside with high sweetness potency and is a potent α-glucosidase inhibitor with an IC₅₀ value of 35.01 ug/mL. Rebaudioside A directly stimulates insulin secretion from pancreatic beta cells via inhibition of ATP-sensitive K⁺-channels.

HY-107754

Cesium chloride	Inhibitor	99.93%
Cesium chloride is a blocker of potassium channel. Cesium chloride prevents the decrease of Na⁺ transport produced by Alloxan. Cesium chloride has induced cardiac arrhythmias, including torsade de pointes in animal models.

HY-N0221

Daurisoline	Inhibitor	99.90%
Daurisoline is a bis-benzylisoquinoline alkaloid that can be isolated from Menispermum dauricum and Rhizoma Menispermi. Daurisoline exerts a blocking effect on hERG and has antiarrhythmic effects. Daurisoline is a potent autophagy blocker that can be used for the research of cancer.

HY-I0352

Epiandrosterone	Activator	99.96%
Epiandrosterone is a steroid hormone. Epiandrosterone activates BKCa. Epiandrosterone inhibits glucose transport and insulin release. Epiandrosterone has weak androgenic activity.

HY-B0254

Glipizide	Inhibitor	99.04%
Glipizide (CP 2872; K 4024)?a potent, orally active and sulfonylurea class anti-diabetic agent and can be used for type 2?diabetes mellitus research but not type 1. Glipizide acts by partially blocking ATP-sensitive potassium?(K_ATP) channels among β cells of pancreatic islets of Langerhans.

HY-B0433A

Quinine hydrochloride dihydrate	Inhibitor	≥98.0%
Quinine hydrochloride dihydrate (Qualaquin) is an orally active and can be used in anti-malarial studies. Quinine hydrochloride dihydrate is a potassium channel inhibitor that inhibits WT mouse Slo3 (K_Ca5.1) channel currents evoked by voltage pulses to +100 mV with an IC₅₀ of 169 μM.

Potassium Channel Compound Library

Compound library containing a variety of potassium channel inhibitors and activators.

270compounds HY-L119

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Potassium Channel

Potassium Channel

Potassium Channel Related Products (796)

Antibodies (6)

Related Compound Screening Libraries (1)

Potassium Channel Related Products (796):